AB0578 SUBCLINICAL ENTHESITIS IN PSORIASIS patiEntS AS prediCtor OF ARTHRITIS (EPESCA STUDY): PRELIMINARY RESULTS

Background: Enthesitis is one of the typical pathological signs spondyloarthritis such as psoriatic arthritis (PsA) and it seems to be Primum movens disease. Clinical assessment enthesitis showed less sensitive, compared ultrasound (US) evaluation, in identifying patients with PsA [1]. OMERACT defined US as: “hypoechoic and/or thickened insertion tendon close bone (within 2 mm from bony cortex), which exhibits Doppler signal if active that may show erosions, enthesophytes/calcifications a sign structural damage” [3] The reported prevalence subclinical psoriasis (PsO) different countries ranges between 7% 20% [2]. Objectives: main objective this study was estimate, by PsO without any clinical enthesitis. Secondary objectives were analyze differences, terms age, sex, BMI, onset diagnosis, among (active or not active), enthesopathy alteration enthesis. According definition enthesitis, divided into 4 groups: (AE) presence power-Doppler hypoechoic bone; patient (En) PD signal; (Ep) damage (erosions, enthesophytes/calcifications); enthesis (WE). Methods: Patients at least 18 years diagnosis made Dermatologist included. Exclusion criteria symptoms articular entheseal involvement, therapy bDMARDs tsDMARDs. All underwent examination on grey scale Power (PD) ultrasonography 6 sites (Achilles, quadriceps, distal proximal patellar, plantar fascia triceps enthesis) bilaterally. Ultrasound performed an experienced sonographer, using Logiq P9 equipped 6-12 MHz broad band linear transducer. Data frequencies median interquartile range. To check differences these four groups, we used chi-square test Kruskall-Wallis test. P-value ≤ 0.05 considered statistically significant. Results: We enrolled 124 consecutive (47 [37.9%] female) age 57.7 (45.3-66.5) years, disease duration 20.4 (10.1-30.8) BMI 27 [24-29]. AE, En, Ep 20.2% (25/124), 49.2% (61/124) 18.5% (23/124), respectively. WE (12.1%, 15/124) significantly lower younger shorter diagnostic delay other patients. enthesopathy/enthesitis more frequently observed Achilles (33.1%, 41/124), (23.4%, 29/124), quadriceps (20.2%, 25/124), patellar (18.5%, 23/124) (4.8%, 6/124) Conclusion: Subclinical quite common patients, about frequent increased older higher BMI. References: [1]Bandinelli F. et al. detects occult involvement early independently features severity. Clin Exp Rheumatology. Mar-Apr 2013;31(2):219-24. [2]Zuliani Ultrasonographic detection synovitis: possible stratification musculoskeletal involvement. Rheumatol Jul-Aug 2019;37(4):593-599. [3]Balint P. V. Reliability consensus-based scoring for arthritis: initiative. Ann Rheum Dis 2018 Dec;77(12):1730-1735. Disclosure Interests: None declared.